Nicotinic Acid

Experience with Nicotinic Acid

Nicotinic Acid Metabolism

Previous reports from this laboratory have described the isolation of 6-hydroxynicotinic acid and 6-0x0-1 ,4,5,6-tetrahydronicotinic acid from the reaction media of a clostridial species grown on nicotinic acid (1). Bn enzyme that catalyzes the reversible oxidation of nicotinic acid to HNA’ has been purified from extracts of this microorganism (2). Since fortified crude extract of this Clostrid...

Tredaptive, INN-nicotinic acid/laropiprant

Bacterial Fermentation of Nicotinic Acid

The ability of certain bacterial species to oxidize nicotinic acid was first reported by Allison (1) who used suspensions of bacteria isolated by Dubos and Miller (2). Koser and Baird (3) later isolated strains of Pseudomonas jluorescens which grew on a synthetic medium in which nicotinic acid was the sole carbon source. These strains did not attack isonicotinic acid, picolinic acid, or pyridin...

Nicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase.

An enzyme that catalyzes the reversible hpdroxylation of nicotinic acid to 6-hydroxynicotinic acid has been purified from extracts of a nicotinic acid-fermenting clostridium. The enzyme appears to be a flavin adenine dinucleotidecontaining non-heme iron protein and utilizes triphosphopyridine nucleotide as the ultimate electron acceptor. The purified enzyme also exhibits reduced triphosphopyrid...